POS-716 SUSTAINED BK VIRURIA: A FORGOTTEN ALLY FOR EARLY DIAGNOSIS OF BK VIRUS NEPHROPATHY IN KIDNEY TRANSPLANTATION
نویسندگان
چکیده
منابع مشابه
BK virus nephropathy and kidney transplantation.
Nephropathy from BK virus (BKV) infection is an evolving challenge in kidney transplant recipients. It is the consequence of modern potent immunosuppression aimed at reducing acute rejection and improving allograft survival. Untreated BKV infections lead to kidney allograft dysfunction or loss. Decreased immunosuppression is the principle treatment but predisposes to acute and chronic rejection...
متن کاملبررسی مولکولی فعالیت مجدد ویروس BK در ادرار بیماران پیوند کلیه
Background & Amis: BK polyomavirus (BKV) is common infection of childhood that persists in kidney epithelium. BKV reactivation characterized by viruria occurs in 35% to 57% of renal allograft recipients. BK virus was detected in serum samples in 6% to 29% of these patients. BKV-associated nephropathy occurs in as many as 8% of renal allograft recipients and may lead to . This study was carri...
متن کاملQuantitation of BK Virus DNA for Diagnosis of BK Virus-Associated Nephropathy in Renal Transplant Recipients
Quantitative measurement of BK virus DNA (Q-BKDNA) has been used for the early diagnosis and monitoring of BK virus-associated nephropathy (BKVAN). This study was designed to determine the BKDNA cutoff for the diagnosis of BKVAN. Between June 2005 and February 2007, 64 renal transplant recipients taken renal biopsies due to renal impairment submitted plasma and urine for Q-BKDNA. Eight BKVAN pa...
متن کاملA Case of BK Nephropathy without Detectable Viremia or Viruria
BACKGROUND BK nephropathy is an evolving challenge among kidney transplant recipients. Diagnosis of BK nephropathy depends on the presence of BK viral inclusions on renal biopsy. Most cases of BK nephropathy are preceded by BK viremia or viruria. CASE REPORT We report a case of BK nephropathy found on protocol renal transplant biopsy without associated BK viremia or viruria. CONCLUSIONS BK ...
متن کاملProgression from Sustained BK Viruria to Sustained BK Viremia with Immunosuppression Reduction Is Not Associated with Changes in the Noncoding Control Region of the BK Virus Genome
Changes in the BK virus archetypal noncoding control region (NCCR) have been associated with BK-virus-associated nephropathy (BKVAN). Whether sustained viremia, a surrogate for BKVAN, is associated with significant changes in the BK-NCCR is unknown. We performed PCR amplification and sequencing of (1) stored urine and (2) plasma samples from the time of peak viremia from 11 patients with sustai...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2021
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2021.03.748